07.11.2019

Strüngmann Group invests in further expansion of CorTec

Today CorTec announced the close of a €13 million funding. The investor consortium is led by Santo Venture Capital, the Strüngmann family holding company. Alongside LBBW Venture Capital, several existing shareholders participate in the funding round. Based on the investments, CorTec plans the next step of expansion with a subsidiary in the USA and the development of the next generation of the Brain Interchange Technology.

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18.01.2018

Wyss Center announces collaboration with CorTec

CorTec and the Wyss Center, a non-profit neurotechnology translation organization, have signed a partnership agreement. They will collaborate in developing a novel, minimally invasive brain monitoring and stimulation device.

The partners will work together on research, design and development of a device for continuous, long-term, monitoring of the brain’s electrophysiological signals for clinical diagnostic and therapeutic applications.

The planned device based on CorTec’s Brain Interchange technology will sit on the skull, beneath the skin and has potential uses in epilepsy monitoring, tinnitus regulation through neurofeedback, neuromodulation for dyslexia and other brain circuit disorders.

The terms of the agreement include the fabrication of novel subcutaneous brain stimulation and monitoring electrodes. The collaboration provides the Wyss Center with exclusive access to novel technology from CorTec for subcutaneous neuromodulation solutions in many promising new applications.

Copyright: Wyss Center

Suitable for long-term implantation, the CorTec Brain Interchange system is an implantable brain stimulation and recording device that allows for chronic closed loop interaction with the brain. The multi-channel system consists of an implanted unit comprising neural electrodes and an electronic unit which both digitizes neural signals and sends stimulation impulses to the neural tissue via the electrodes. It communicates wirelessly with a body-external telemetry unit which is also responsible for power supply. The telemetry unit communicates with a computer that controls the application autonomously based on the recorded data and enables a needs-oriented therapy.

Professor John Donoghue, Director of the Wyss Center said: “Our partnership with CorTec could result in far reaching benefits for many neurotech device development projects underway today. CorTec’s existing technologies, along with their enthusiastic approach to research and innovation, makes them an ideal partner for the Wyss Center. We are looking forward to working together to help people with nervous system disorders regain their independence.”

“At the Wyss Center we are developing a minimally invasive device for the chronic recording of global brain signals. The system will also be capable of electrical stimulation, for diagnostic and therapeutic applications.” said George Kouvas, Programme Manager. “The collaboration with CorTec will accelerate this development and enable us to progress to clinical trials more quickly for the benefit of people with brain circuit disorders.”

“In a very short time the Wyss Center has built impressive facilities and a highly skilled team heading with verve for innovative personalized neurotherapies. We are looking forward to working with John Donoghue and the people at the Wyss Center to realize novel therapies,” commented CorTec CEO Joern Rickert, Ph.D., on the collaboration.

Martin Schuettler, Ph.D., CTO and CEO at CorTec added: “Until now many innovative therapy approaches could not be developed because suitable technology was lacking. Together with the Wyss Center we can close this gap based on our Brain Interchange system while at the same time pushing the boundaries of our current technology by exploring new methods and materials.”

Further development and optimization of existing minimally invasive long-term monitoring devices has the potential to accelerate multiple neurotechnology applications and could revolutionize the diagnosis and treatment of neurodisorders.

Learn more about epilepsy treatment and the Wyss Center.

Download the full press release: CorTec_PressRelease_01-2018

05.10.2017

Little Girl Overcomes Big Disease – Thanks to Latest Technology

For the first time an intervention based on tailor-made electrodes from CorTec was performed at the University Hospital of Goethe University in Frankfurt: The seven-year-old girl with epilepsy is seizure-free since the surgery.

Epilepsy is an extremely devastating disease, in particular in children like seven-year-old Nora. Until now her day was dominated by up to 30 epileptic seizures which were so strong that she would frequently become unconscious and fall over on such an event. Since the seizures were completely unpredictable and could attack the little girl all of a sudden at any time Nora had to be monitored around the clock such that somebody could immediately succor her and to prevent her from injuring herself when a seizure would strike.

A normal child’s life with going to kindergarten and school or just playing with friends was impossible for Nora. The disease also strongly inhibited her physical and mental development. Currently available drugs did not offer sufficient relief to Nora – as is the case for roughly one third of all epilepsy patients in general.

Thanks to a new technology Nora finally got help at the Center of Neurology and Neurosurgery (CNN) at University Hospital Frankfurt.  A custom-made electrode grid from CorTec supported the pre-operative diagnostics intended to identify the brain tissue that was involved in generating the epileptic seizures and that was supposed to be removed afterwards. A high number of electrode contacts covered the affected brain areas precisely. This enabled an optimal localization of the diseased tissue and healthy areas that should be preserved as best as possible during surgery.

Dr. Martin Schüttler, chief technology officer at CorTec, explains how this new type of electrode grids is produced: “Based on individual MR images from the brain of the patient we tailored the electrode for her according to the requirements of the University Hospital. The innovative laser-aided manufacturing technology that we use at CorTec allows the production of very soft and thin contact mats which thanks to their flexibility adapt to the curved surface of the brain.”

For several days Nora’s brain was ‘mapped’ in detail to identify healthy and diseased brain regions exactly. During a five-hour surgery afterwards at CNN neurosurgeon Dr. Thomas Freiman was able to precisely remove the problematic region.

AirRay_8x8_Grid_with_Cable_Label

“The remarkable softness and flexibility of the CorTec electrode as well as its individual tailoring to the patient have been extremely valuable for the particularly difficult surgery that we had to perform on this child,” says Freiman. “The electrode proved to be very gentle and tissue-friendly. Even after 10 days of implantation it was still exceptionally well tolerated by the body. We did not observe any undesirable but frequent side effects such as bleeding”.

The surgical procedure was remarkably successful. From the day of surgery Nora has been seizure-free, something that has not happened ever since the onset of the disease. Now she is looking forward to a six-month rehabilitation period during which she will recover at her own pace and catch up on important development steps. All results indicate that the surgery has successfully overcome the disease with the help of latest technology. To the small patient new prospects are opening up on a normal life as a child and later also as an adult.

 

 

Learn more about epilepsy treatment at the Center of Neurology and Neurosurgery at University Hospital Frankfurt

Download the full press release: CorTec_PressRelease_03-2017