Precision in the Peripheral Nervous System

How imec is advancing bioelectronic medicine

 

The medicine of the future will increasingly rely not just on chemistry, but on precision electronics. Our partner imec is advancing a new, minimally invasive technique for selective stimulation of the peripheral nervous system (PNS). While peripheral nerve stimulation is already an established treatment modality, current methods often lack precision and can lead to unwanted side effects. Imec’s approach focuses on targeting specific nerve fibers with high accuracy, potentially reducing side effects and improving therapeutic outcomes. This enhanced selectivity opens the door to treating conditions such as inflammation, chronic pain, or organ dysfunction more effectively – and in some cases, it may even offer an alternative to drug-based therapies.

To Learn More About Bioelectronic Medicine Visit our Application Page.

 

CorTec provides the high-precision cuff and cable electrode for imec’s selective peripheral nerve (sPNS) stimulation solution. This is a key component to enable bidirectional communication with the nervous system – both the reading of neuronal signals and their targeted stimulation. This technology creates the basis for intelligent, adaptive therapy systems that can react to the patient’s condition in real time.

Imec’s solution enables a closed-loop system that continuously monitors, interprets and immediately reacts to the activity of the nervous system – for dynamic, individualized therapy that adapts automatically. The goal is a miniaturized, implantable system that can remain in the body long-term and can communicate wirelessly with external electronics.

“Our collaboration with CorTec marks a pivotal step in advancing closed-loop and selective peripheral nerve stimulation, combining our expertise in chip and system development, with CorTec’s enabling technology. It allows us to serve our customers through integrated solution and shared vision”

— Patrick Van Deursen, Program Director Health at imec

Fields of application: New approaches to chronic diseases

The most promising areas of application include chronic inflammatory diseases such as Crohn’s disease or rheumatoid arthritis. By stimulating certain nerves, such as the vagus nerve, the overactive immune response can be specifically influenced. Autonomic dysfunctions (e.g. in the bladder or bowel), chronic pain or neuropsychiatric indications are also among the potential fields of application.

The vision: implant systems that are in close dialog with the nervous system, detect changes at an early stage and immediately intervene therapeutically – without medication, but with a lasting effect.

A shared vision becomes reality

Imec is driving forward neuromodulation chip development, while CorTec is providing the enabling component that makes this technology possible. Together, they pave the way for a new generation of peripheral nerve stimulation systems: precise, intelligent, and personalized. The combination of microtechnology, neural intelligence and system integration opens up completely new perspectives in medical technology – more precise, more individual and more sustainable than ever before.

We at CorTec are proud to be a part of this electrifying future of medicine with our technology – together with imec and other strong partners on the way to the next generation of bioelectronic therapies. This is how we are shaping the future of medicine that thinks electrically and puts people at the center.

To learn more about imec visit their website.

More content on this project by imec can be found here: https://www.imec-int.com/en/expertise/health-technologies/implantable-devices/selective-peripheral-nerve-stimulation-pns

 

Further readings in User Stories:

The Power of Active Implant Sytems

Active implant systems are the foundation of modern neurotechnology. It enables precise, bidirectional communication with...

Interview with Mariska van Steensel: Inside the INTENSE Project

Dr. Mariska van Steensel from University Medical Center Utrecht shares insights from the INTENSE Project,...

CorTec: Your Partner for Fully Integrated Neuromodulation & Medical Device Solutions 

Bringing a neuromodulation medical device to clinical reality is rarely just engineering. It is a...

Brain Interchange System Sets a New Standard

The recent publication in Nature Scientific Data by the research group around Takufumi Yanagisawa at...

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SPECIFICATIONS

FEATURE 

Recording channels 

Sampling rate 

Sampling dynamic range 

High pass filter cut-off 

Low pass filter cut-off 

Amplifier band pass gain 

Band pass roll-off 

Reference


Stimulation 

Stimulation channels 

Current 

Current source 

Pulse width 

Power supply 

Wireless data transmission 

Closed Loop latency

VALUE

32 

1 kHz 

16 bit (74 nV smallest increment) 

ca. 2 Hz 

325 Hz 

Adjustable: 100-750 

20 dB/dec 

Any (subset) of the recording channels selectable by software or one dedicated hard-wired additional contact 

Current-controlled, biphasic, rectangular, asymmetric stimulus pulses (cathodic amplitude with pulse width followed by an anodic counter pulse of 1/4x amplitude and 4x pulse width) 

 32 

Max. -6 mA / +1.5 mA (24 µA increments) within

 compliance voltage range of -11 V to +5 V 

Can be directed to any of the 32 electrode contacts 

Negative phase: 10 µs – 2,500 µs

Wireless inductive, 120-140 kHz

Bi-directional, radio frequency in 2400-2483.5 MHz band ≤ 40 ms